Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological targets and you will pharmacology away from curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca M. Romero, Ian S Haworth Curcumin is the major part of the latest red color off turmeric, an Indian liven that’s taken from the new rhizome of your tropical bush Curcuma longa, and therefore is one of the Zingiberaceae relatives. Within this chapter, i talk about the pharmacological affairs off curcumin and you can discuss brand new molecular basics for those circumstances. We up coming remark the new demonstrated and you will prospective health-related spends off curcumin. Curcumin is famous usually once the a curative representative, however, the method off action was in depth. The latest pharmacological effects of curcumin seem to be the result of an effective synergism away from companies out of weak biochemical affairs that have multiple physiological plans into the interrelated signaling pathways. Such aim is enzymes like cyclooxygenase, lipoxygenase and you can protein kinases, and you may transcription points particularly NF-?B, STAT and you can Nrf2. Modulation of them molecules affects downstream affectors that produce brand new antiinflammatory, anti-oxidant, chemopreventive, anticancer kissbrides.com navigera till webbplatsen, and antimicrobial items out of curcumin. These outcomes was checked within the clinical examples off curcumin getting discomfort and you can inflammatory ailment, cancer tumors, Alzheimer situation, cardio diseases, and you will diabetes. The new samples have tried varying dosage out-of curcuminwith various other wavelengths and course, for the general conclusion one to higher amounts out of curcumin during the number of g must receive therapeutic effects. Find out more
Curcumin: Synthesis, Emerging Character during the Discomfort Government and you may Health Ramifications
Publication Part Examples of bush-derived pharmaceuticals having become the desire of continuing and you may rapid look and you may creativity focus provides, up until now, become a bit scarce. After a long period, the past 20 years was characterized by good 100-bend boost in the number of medical stuff composed a-year one was regarding value on use of curcumin inside the biomedicine. Read more
Build, synthesis and you may physical items out-of curcumin prodrugs
Book ChapterAsma Este-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin has some possible pharmacological effects and will has therapeutic apps a number of problem states, because the talked about in detail in the earlier section. However, the potential systematic effectiveness regarding curcumin is bound of the its physicochemical services regarding terrible water solubility and you may instability, and that bring about lower bioavailability. Prodrugs out of curcumin provide an approach to improvement of the biopharmaceutical and pharmacokinetic properties, and may also create exploitation of pharmacological outcomes of curcumin. Within this chapter, i very first opinion the newest physicochemical and you may pharmacokinetics from curcumin. I then establish the design of curcumin prodrugs which have improved water solubility and you may improved chemical compounds stability which may be converted back to 100 % free curcumin upon bioactivation inside vivo. I emphasize previous success of this type, having a concentrate on the build, synthesis and you will investigations away from prodrugs considering promoieties together with proteins, essential fatty acids, nucleic acids, dicarboxylic acids, and polymeric content such hyaluronic acidic and you may polyethylene glycol. So it section has the reason behind optimisation of your own physicochemical and biopharmaceutical attributes therefore the biological points from curcumin prodrugs, into the mission using of them curcumin derivatives within the logical programs. Find out more